Physiology and Biophysics

September 23, 2020

SHAC seminar co-host with Bloedel “One receptor, two surprises”

June 2, 2022 @ 3:30 pm – 4:30 pm
G-328 and
HOLDING – co-host with Bloedel SHACS series

One receptor, two surprises: unexpected mGluR-mediated neuromodulation in sound localization circuits

Yong Lu, PhD

Professor of Anatomy and Neurobiology
College of Medicine
Northeast Ohio Medical University (NEOMED)
Abstract: Neuromodulation affects brain function and development. We investigated neuromodulation mediated by group I metabotropic glutamate receptors (mGluR I) in the brainstem sound localization circuits. Activation of mGluR I exerts differential modulation of synaptic transmission depending on the transmitter type and its release mode. Furthermore, the modulation generates temporally patterned spontaneous synaptic responses, implying a potential central mechanism underlying the spontaneous activity necessary for the development of the sound localization circuits. website: