One receptor, two surprises: unexpected mGluR-mediated neuromodulation in sound localization circuits
Yong Lu, PhD
Professor of Anatomy and Neurobiology
College of Medicine
Northeast Ohio Medical University (NEOMED)
Abstract: Neuromodulation affects brain function and development. We investigated neuromodulation mediated by group I metabotropic glutamate receptors (mGluR I) in the brainstem sound localization circuits. Activation of mGluR I exerts differential modulation of synaptic transmission depending on the transmitter type and its release mode. Furthermore, the modulation generates temporally patterned spontaneous synaptic responses, implying a potential central mechanism underlying the spontaneous activity necessary for the development of the sound localization circuits.