Mechanisms of mitochondrial calcium uptake — structure, function, and tissue-specific regulation.
Ming-Feng Tsai, Ph.D.
Department of Physiology and Biophysics, University of Colorado School of Medicine
Mitochondrial calcium uptake regulates key cellular processes, including ATP synthesis, cell death, and intracellular calcium signaling. It is important in virtually all aspects of human physiology, and its malfunction is implicated in detrimental diseases, such as heart failure, neurodegeneration, cancer metastasis, among others. In this talk, I will present our previous studies regarding the molecular mechanisms of a multi-subunit calcium channel called the mitochondrial calcium uniporter, which is the protein complex that mediates mitochondrial calcium uptake. I will also use the cardiac tissue as an example to share our ongoing efforts to understand how the uniporter is regulated in a tissue-specific manner to adapt to unique intracellular calcium signaling systems in different types of cells.
The department of Physiology & Biophysics acknowledges the Coast Salish peoples of this land, the land which touches the shared waters of all tribes and bands within the Suquamish, Tulalip and Muckleshoot nations. It is in this land where we work, teach, and learn.