James Trimmer

The restricted and dynamically regulated subcellular localization of signaling proteins in highly differentiated cells such as mammalian neurons defines intra- and inter-cellular signaling events.  Among neuronal proteins exhibiting the most highly compartmentalized expression are ion channels, whose localization at specific sites can both define signaling in that neuronal compartment, but also allow for discrete regulation of the population of channels found at these sites. I will describe the diverse mechanisms that establish, maintain and dynamically regulate ion channel expression at specific sites to support neuronal function and confer plasticity to neuronal signaling.