Where the kidney meets the heart: calcium signaling, cardiomyopathies and polycystic kidney disease
Polycystin 2 mutations lead to polycystic kidney disease (PKD), a condition with no cure. Although cysts are the defining characteristic of PKD, cardiac dysfunction is the main cause of mortality, however, the underlying reasons are not known. Polycystin 2 acts both as an intracellular calcium channel and a modulator to alter intracellular signaling pathways. I will present evidence demonstrating that perturbations to calcium signaling result in cysts. Second, I will show that mutations and decreased availability of polycystin 2 results in cardiac dysfunction. Understanding the molecular actions of polycystin 2 in multiple tissue settings will help direct therapeutic efforts into treating PKD.
Ivana Yih-Tsue Kuo, PhD,
Chalk talk, Friday, January 29th, at 9:30 in G-417.
The department of Physiology & Biophysics acknowledges the Coast Salish peoples of this land, the land which touches the shared waters of all tribes and bands within the Suquamish, Tulalip and Muckleshoot nations. It is in this land where we work, teach, and learn.