Physiology and Biophysics
August 5, 2015
Ivana Yih-Tsue Kuo, PhD, Yale University
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January 28, 2016 @ 9:30 am – 10:30 am
Polycystin 2 mutations lead to polycystic kidney disease (PKD), a condition with no cure. Although cysts are the defining characteristic of PKD, cardiac dysfunction is the main cause of mortality, however, the underlying reasons are not known. Polycystin 2 acts both as an intracellular calcium channel and a modulator to alter intracellular signaling pathways. I will present evidence demonstrating that perturbations to calcium signaling result in cysts. Second, I will show that mutations and decreased availability of polycystin 2 results in cardiac dysfunction. Understanding the molecular actions of polycystin 2 in multiple tissue settings will help direct therapeutic efforts into treating PKD.Ivana Yih-Tsue Kuo, PhD, Yale University Chalk talk, Friday, January 29th, at 9:30 in G-417.