Physiology and Biophysics

April 21, 2016

PBIO Seminar Series: Gabriela Popescu

November 10, 2016 @ 9:30 am – 10:30 am
HSB G-328
Andres Barria

NMDA Receptors: learning from singles and beyond

Gabriela Popescu, PhD ProfessorDepartment of Biochemistry, Jacobs School of Medicine and Biomedical SciencesUniversity of Buffalo Popescu Laboratory Abstract NMDA receptors are members of the tetrameric ionotropic glutamate receptor family that fulfill unique and critical roles during the normal development and function of the central nervous system. These roles are supported by characteristic kinetic attributes of the glutamate-evoked output, which in turn reflect the receptor’s operation. In this talk, I will review the biologically salient features of the NMDA receptor response and describe recent mechanistic insights afforded by kinetic modeling of one channel currents. In addition, I will present unpublished data on novel modalities of gating host: Andres Barria