Physiology and Biophysics

December 19, 2017

PBIO seminar CANCELED for Bret Smith

March 26, 2020 @ 9:30 am – 10:30 am


“Synaptic reorganization and epileptogenesis after traumatic brain injury”

Development of acquired temporal lobe epilepsy (TLE) is often accompanied by reorganization of synaptic circuitry in the temporal lobe.  In particular, the axons of dentate gyrus granule cells ‘sprout’ and form new connections with other granule cells, as well as hilar interneurons, after status epilepticus (SE) or traumatic brain injury (TBI).  Synaptic reorganization could promote seizures, but could also represent a compensatory mechanism.  This seminar discusses functional attributes of synaptic reorganization in two mouse TLE models. Bret N Smith, PhD Professor and Chair Department of Neuroscience Professor of Physiology Director, Epilepsy Research Center (EpiC) University of Kentucky College of Medicine host: Nick Poolos