“Synaptic reorganization and epileptogenesis after traumatic brain injury”
Development of acquired temporal lobe epilepsy (TLE) is often accompanied by reorganization of synaptic circuitry in the temporal lobe. In particular, the axons of dentate gyrus granule cells ‘sprout’ and form new connections with other granule cells, as well as hilar interneurons, after status epilepticus (SE) or traumatic brain injury (TBI). Synaptic reorganization could promote seizures, but could also represent a compensatory mechanism. This seminar discusses functional attributes of synaptic reorganization in two mouse TLE models. Bret N Smith, PhD
Professor and Chair
Department of Neuroscience
Professor of Physiology
Director, Epilepsy Research Center (EpiC)
University of Kentucky College of Medicine host: Nick Poolos
Mechanisms underlying flexible information flow across the brain Karel Svoboda, Ph.D. Director, Allen Institute: Abstract: Neural computation and behavior are produced by shifting configurations of multi-regional neural networks, implemented by dynamic coupling between brain regions. We...