“Synaptic reorganization and epileptogenesis after traumatic brain injury”
Development of acquired temporal lobe epilepsy (TLE) is often accompanied by reorganization of synaptic circuitry in the temporal lobe. In particular, the axons of dentate gyrus granule cells ‘sprout’ and form new connections with other granule cells, as well as hilar interneurons, after status epilepticus (SE) or traumatic brain injury (TBI). Synaptic reorganization could promote seizures, but could also represent a compensatory mechanism. This seminar discusses functional attributes of synaptic reorganization in two mouse TLE models.
Bret N Smith, PhD
Professor and Chair
Department of Neuroscience
Professor of Physiology
Director, Epilepsy Research Center (EpiC)
University of Kentucky College of Medicine
host: Nick Poolos
The department of Physiology & Biophysics acknowledges the Coast Salish peoples of this land, the land which touches the shared waters of all tribes and bands within the Suquamish, Tulalip and Muckleshoot nations. It is in this land where we work, teach, and learn.
