August 5, 2015
Andy J. Chang, PhD, Stanford
A molecular mechanism of acute oxygen sensingWhile the molecular mechanism for slower adaptations to low oxygen (hypoxia) is known, mechanisms for rapid oxygen sensing are not well understood. Located at the bifurcation of the carotid artery in the neck, the mammalian carotid body is a chemosensory organ that senses decreases in blood oxygen to stimulate breathing within seconds. I will present the identification of an acute oxygen-sensing pathway in the mouse carotid body that senses hypoxia indirectly through detection of a metabolite. Andy J. Chang, PhD Stanford University Chalk Talk on Friday, February 5th, 9:30am in G-417.