Cytoplasmic Dynein and Kinesins in Brain Development and Autophagy
Microtubule Motor Proteins Are Involved in a Wide Range of cellular activities. Recent work in our lab has involved the role of the motor proteins in neuronal migration and neurogenesis in the developing brain. We have worked out mechanisms by which cytoplasmic dynein, its regulators Nde1 and Ndel1, and LIS1 and the kinesin Kif1a contribute to these functions as well as brain developmental disease. We have also found a new role for the dynein adaptor protein RILP as a master regulator of mTOR-dependent autophagy in neurons. Richard Vallee Professor of Pathology & Cell Biology
Columbia University time: 4:00pm
location: HSB, T-639 host: Stanley C. Froehner
Mechanisms underlying flexible information flow across the brain Karel Svoboda, Ph.D. Director, Allen Institute: Abstract: Neural computation and behavior are produced by shifting configurations of multi-regional neural networks, implemented by dynamic coupling between brain regions. We...